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Aqualyx: Non-Surgical Adipocytolysis – Everything You Need to Know

by | May 12, 2025 | Marllor Biomedical

Aqualyx intralipotherapy has established itself as a non-surgical alternative for reducing localized fat deposits. This treatment has gained popularity among aesthetic medicine professionals due to its efficacy and safety profile. In this article, we will comprehensively explore Aqualyx’s mechanism of action, application protocol, comparisons with alternatives such as Kybella and liposuction, and key considerations for clinical practice.

What is Aqualyx?

Aqualyx is an injectable solution designed to eliminate localized fat deposits. Its main active ingredient is deoxycholic acid, a substance naturally found in human bile that aids in fat emulsification during digestion. When injected into adipose tissue, Aqualyx induces the destruction of fat cells—a process known as adipocytolysis. The cellular debris is subsequently eliminated through the lymphatic system and excreted from the body.

Mechanism of Action

Deoxycholic acid acts as a detergent that breaks down the cell membranes of adipocytes, leading to their lysis. This process is specific to fat cells, minimizing damage to surrounding tissues when administered correctly. Aqualyx also contains galactose polymers that help control the release of deoxycholic acid, reducing diffusion into unwanted tissues and improving patient tolerance.

Application Protocol

Patient Assessment

Before starting treatment, a thorough evaluation of the patient is essential, including medical history, expectations, and targeted areas. Aqualyx is indicated for patients with localized fat deposits that do not respond to diet or exercise. It is not a treatment for generalized obesity.

Injection Technique

Aqualyx is applied via intralipotherapy using specialized needles such as Lipoinject. The solution is injected directly into adipose tissue in a fan-shaped pattern to ensure even distribution. Lidocaine is commonly added to enhance tolerance.

Number of Sessions

The number of sessions depends on the treatment area and fat volume. Typically, 2 to 6 sessions are required, spaced 3 to 4 weeks apart. Results begin to appear from the second or third week after treatment.

Post-Treatment Care

Post-session care includes avoiding heat exposure, intensive massage, and strenuous physical activity for at least 48 hours. Cold compresses and compression garments can help reduce swelling and improve patient comfort.

Comparison With Alternatives

Aqualyx vs. Kybella

Kybella is another injectable treatment based on deoxycholic acid, FDA-approved for submental fat reduction. While Kybella is specifically indicated for the chin area, Aqualyx has a broader range of applications including abdomen, flanks, thighs, and arms. Additionally, Aqualyx’s formulation with polymers modulating the acid release may result in reduced inflammation post-treatment.

Aqualyx vs. Liposuction

Liposuction is a surgical procedure that removes large volumes of fat in a single session. However, it carries surgical risks such as infection, bruising, and prolonged recovery times. Aqualyx, being non-invasive, has a more favorable safety profile and shorter recovery periods, although multiple sessions may be needed to achieve comparable results in specific areas.

Clinical Efficacy

Clinical studies have demonstrated Aqualyx’s efficacy in reducing localized fat. For instance, a study published in the journal of the Spanish Society of Aesthetic Medicine evaluated intralipotherapy with sodium deoxycholate in the trochanteric region. It reported an average reduction of 1.3 cm in circumference after three sessions. When combined with carboxytherapy, the average reduction increased to 2.7 cm, along with improvements in skin texture and patient satisfaction (seme.org).

Safety Considerations

Although Aqualyx is generally safe, it must be administered by trained professionals. Improper administration can lead to complications such as excessive swelling, bruising, infections, or, in rare cases, tissue necrosis. Proper patient selection, precise injection technique, and adherence to aseptic protocols are crucial to minimizing risks.

Conclusion

Aqualyx is an effective and safe option for non-surgical fat reduction. Its targeted mechanism of action, combined with a well-structured application protocol, allows for satisfactory outcomes across various body areas. As a leading solution in the field of Aqualyx: non-surgical adipocytolysis, it offers a minimally invasive alternative to traditional procedures. However, aesthetic medicine professionals must be well-trained and adhere to best clinical practices to ensure treatment efficacy and patient safety.

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