Product range, NASHA/OBT technology, comparative studies
Restylane hyaluronic acid was the first dermal filler approved by the FDA in 2003 for aesthetic use. Developed by Galderma, it has maintained leadership thanks to scientific validation, safety, and versatility. Today, the Restylane hyaluronic acid portfolio covers everything from fine lines to contouring and volume restoration in the face and lips.
NASHA™ vs OBT™ Technology: science and personalization
Restylane stands out for featuring two types of hyaluronic acid crosslinking technologies:
| Technology | Description | Ideal Indications |
|---|---|---|
| NASHA™ | Firmer, more structured particles | Contouring, projection, deep wrinkles |
| OBT™ | Softer, more flexible gel | Lips, cheeks, subtle corrections |
- NASHA is recommended for areas requiring firmness and long-lasting definition.
- OBT provides adaptability, ideal for areas with high mobility.
Full Restylane Product Line
| Product | Technology | Primary Indications | Estimated Longevity |
| Restylane Classic | NASHA | Nasolabial folds, marionette lines | 6–9 months |
| Restylane Lyft | NASHA | Cheeks, chin, jawline volume | 12–18 months |
| Restylane Kysse | OBT | Lip enhancement and definition | 9–12 months |
| Restylane Refyne | OBT | Perioral lines, superficial wrinkles | 6–9 months |
| Restylane Volyme | OBT | Global facial volume restoration | 12 months |
Source: Galderma Aesthetics
Clinical Studies and Scientific Evidence
Restylane is one of the most documented dermal fillers in scientific literature. Notable studies include:
- Fagien S, Carruthers JD et al., 2013: Compared Restylane to other fillers for moderate to severe wrinkles. Result: high satisfaction and durability.
View study on PubMed - Rzany B, Monheit GD et al., 2011: Long-term safety evaluation. Conclusion: low rate of adverse effects.
Access study - Carruthers A, et al., 2010: Use of Restylane for midface volume. Result: sustained improvement up to 18 months.
Summary here
Comparison with Other Hyaluronic Acid Fillers
| Brand | Technology | Firmness Profile | Key Indications |
| Restylane | NASHA / OBT | Broad spectrum | Facial volume, lips, contour |
| Juvéderm | Hylacross/Vycross | Softer | Lip hydration and contouring |
| Belotero | CPM™ | Ultra-fine | Superficial wrinkle correction |
Safety Profile and Side Effects
Restylane products are approved by both the FDA and EMA. They are known for:
- Low risk of adverse events.
- Biocompatibility due to stabilized hyaluronic acid.
- Reversibility with hyaluronidase if needed.
Common side effects include mild edema, bruising, tenderness at the injection site, and rarely, subcutaneous nodules.
Advantages for the Aesthetic Medicine Professional
- Broad portfolio for personalized treatment.
- High patient retention due to natural results.
- Ongoing training and professional support from Galderma.
Conclusion
Restylane offers a comprehensive solution for aesthetic medicine, backed by safety, science, and natural-looking outcomes. With its dual technology (NASHA/OBT), high-level clinical studies, and its versatility in facial and lip applications, it remains an essential tool in injectable aesthetic treatments.
One of the key advantages of Restylane hyaluronic acid fillers is their adaptability to a wide range of patient needs and aesthetic goals. Whether the objective is subtle lip enhancement, structural contouring, or deep wrinkle correction, the Restylane portfolio provides targeted options that align with each indication. The flexibility of its product line enables medical professionals to customize treatments with greater precision, achieving results that respect the anatomy and unique characteristics of each patient.
In addition, Restylane’s safety record is one of the most robust in the industry. Clinical trials and real-world applications have consistently shown low incidence of adverse effects, especially when used by experienced injectors with proper training. The ability to reverse the product using hyaluronidase also adds a layer of reassurance for both professionals and patients.
From a business perspective, incorporating Restylane into an aesthetic practice enhances professional credibility and patient trust. As a product developed by Galderma—a globally respected leader in dermatology—Restylane benefits from ongoing scientific research, innovation, and educational support. These resources empower practitioners to stay updated on best practices, new techniques, and product advancements.
Finally, as patient demand continues to grow for non-surgical, minimally invasive aesthetic procedures, Restylane’s combination of clinical reliability, artistic versatility, and enduring results makes it a cornerstone in any modern aesthetic portfolio. Its track record and ongoing evolution position it not just as a filler, but as a platform for safe, refined, and science-driven facial rejuvenation.
Resources and Official Sources
- Official Restylane Site – Galderma
- PubMed – Restylane Studies
- FDA – Medical Devices
- ClinicalTrials.gov