A Dual-Plane Strategy for Structural Support and Advanced Dermal Redensification with Glycerol-Stabilized Hyaluronic Acid.
In current aesthetic medicine, the approach to facial aging has shifted significantly from merely chasing wrinkles to three-dimensional restoration and total improvement of ‘Skin Quality.’ Achieving optimal, natural-looking results rarely relies on a single product; rather, it depends on understanding the clinical synergy of Saypha Volume vs Rich and how their different rheological properties interact with specific anatomical planes. The combined application of these solutions, developed by Croma-Pharma, provides a comprehensive approach to simultaneously address the loss of deep structural support and superficial dermal elastosis. This article outlines the technical justification and clinical protocol for this dual approach.
1. Technical Analysis: Defining the Tools
To implement an effective dermal redensification and volumetric protocol, it is crucial to differentiate the chemical and mechanical profiles of these two distinct medical devices.
Saypha Volume: The Structural Pillar
Saypha Volume is a highly cross-linked hyaluronic acid (HA) gel utilizing Croma’s proprietary S.M.A.R.T. (Supreme Monophasic and Reticulated Technology). Its high viscosity and significant G’ (prime) modulus give it superior lifting capacity, making it the ideal choice for correcting deep volumetric deficits.
- Concentration: 23 mg/mL cross-linked HA.
- Cross-linking Agent: BDDE (lowest effective concentration).
- Primary Indication: Rejuvenation of the malar region, chin augmentation, deep nasolabial folds, and facial contour remodeling.
Saypha Rich: The Extracellular Matrix Optimizer
Unlike conventional fillers designed for projection, Saypha Rich is a non-cross-linked HA stabilized with Glycerol. This polyalcohol functions not only as a potent hydrating agent but also as an osmoprotectant and thermal stabilizer, creating an optimal physiological environment for fibroblast activity.
- Concentration: 18 mg/mL non-cross-linked HA + 20 mg/mL Glycerol.
- Mechanism of Action: Deep hydration, antioxidant protection for the HA chains, and replenishment of transepidermal water loss (TEWL).
- Primary Indication: Improvement of skin elasticity (turgor), treatment of fine lines (e.g., perioral “barcodes”, crow’s feet), and revitalization of areas with thin skin like the neck and décolletage.
2. Comparative Table of Rheological Properties & Indications
Understanding the rheology is key to placing the product in the correct tissue plane to avoid complications like the Tyndall effect or visible lumps.
| Feature | Saypha Volume | Saypha Rich |
| HA Type | Highly Cross-linked (S.M.A.R.T.) | Non-cross-linked + Glycerol |
| Rheology (G’ Modulus) | High G’ (Firmness & Lift capacity) | Low G’ (High fluidity & diffusion) |
| Injection Plane | Deep Dermis / Supraperiosteal / Subcutaneous | Superficial to Mid-Dermis |
| Clinical Objective | Projection, Volumization, and Structural Support | Hydration, Glow, and Dermal Redensification |
| Estimated Duration | 9 to 12 months (depending on area) | Protocol of 3 sessions (1 every 3 weeks) for peak results |
3. The Combined Protocol: The “Sandwich Technique” for Structure and Quality
Combining these two products allows the clinician to address aging in a “layered” manner, treating structural fat loss and superficial elastosis either in a single session or a sequential treatment plan.
Phase A: Structural Repositioning with Saypha Volume
Before addressing skin quality, the underlying framework must be restored.
- Assessment: Identify key deflation points in the mid-face (e.g., Hinderer’s points, zygomatic arch).
- Technique: Deep bolus injections or retrograde linear threading, depending on the area.
- Tool: A 25G or 27G cannula is recommended to minimize tissue trauma and vascular risks in deep planes.
- Clinical Goal: Restore the facial “V-shape” and provide the necessary scaffold so that superficial tissues sit correctly.
Phase B: Dermal Redensification with Hyaluronic Acid and Glycerol (Saypha Rich)
Once volume is restored, the quality of the overlying skin becomes paramount. A restored cheekbone under crepey, dehydrated skin will look unnatural.
- Technique: Serial micropapules or “nappage” technique in areas of high laxity.
- Critical Zones: Lateral cheeks (pre-auricular), periorbital region, and superficial perioral lines.
- The Glycerol Synergy: The glycerol in Saypha Rich protects the HA chains from rapid degradation by free radicals and contributes to sustained hydration, creating a lasting “glow” effect that pure non-cross-linked HA often lacks.
Clinical Note: The use of hyaluronic acid with glycerol has been shown in various dermatological studies to significantly improve skin roughness and cutaneous elasticity after just two sessions, making it a cornerstone treatment for photoaging (Glogau types II-III).
4. Clinical Practice Benefits of Croma Pharma Protocols
Adopting integrated Croma Pharma protocols enhances aesthetic outcomes and optimizes clinic operations:
- Natural Results: By treating distinct anatomical planes with appropriate rheologies, you avoid the “overfilled syndrome” or “pillow face” often caused by using high G’ fillers too superficially.
- Versatility: The protocol is highly customizable to the patient’s specific degree of aging.
- Safety Profile: Both products boast exceptional purity levels due to Croma’s manufacturing standards, minimizing post-treatment inflammatory reactions.
5. Official Sources and Scientific References
For further investigation into the clinical evidence supporting the Saypha range and S.M.A.R.T technology, please consult the following professional resources:
- Croma-Pharma Official Website (Professional Area): Product Portfolio and Science
- Scientific Literature on Glycerol in HA: Journal of Cosmetic Dermatology or similar databases often feature studies on the osmoprotective properties of glycerol combined with HA for skin revitalization. (Ensure to reference current literature available through PubMed).
- IFU (Instructions for Use): Always consult the specific technical manuals for Saypha Volume and Saypha Rich for a complete list of contraindications, warnings, and injection guidelines.
Disclaimer: This article is intended for informational purposes for medical professionals only. It does not replace official training or the Instructions For Use (IFU) provided by the manufacturer.