In the field of aesthetic medicine, Profhilo has emerged as a groundbreaking treatment that combines deep hydration with biological stimulation of the skin—without adding volume or altering facial features. Unlike traditional fillers, Profhilo hyaluronic acid acts as a tissue biostimulator, enhancing skin quality from within through its unique formulation and the strategic BAP injection technique.

This article explores Profhilo’s unique properties, clinical evidence, and how it compares to other injectable treatments in modern aesthetic practice.

What is Profhilo and What Makes It Unique?

Profhilo is an injectable product developed by IBSA Derma that contains 64 mg of ultrapure hyaluronic acid in a single 2 ml syringe. It is neither a classic filler nor a skinbooster, but rather a skin biostimulator that improves firmness, elasticity, and hydration without altering facial volume.

Unlike conventional fillers, it is not chemically cross-linked and contains no BDDE. It uses patented NAHYCO® technology, which thermally stabilizes high- and low-molecular-weight hyaluronic acid chains, resulting in a highly spreadable, integrated product that stimulates fibroblasts and deeply hydrates the skin.

Dual Mechanism: Hydration and Biostimulation

Profhilo works in two key ways:

• Deep hydration: Its high HA concentration attracts water into the dermis, improving turgor, radiance, and texture.
• Bioremodeling: It activates fibroblasts to produce collagen types I and III, elastin, and endogenous hyaluronic acid, reinforcing the skin matrix.

The result is visibly healthier, firmer, and more elastic skin—without modifying its natural contours.

Application Technique: BAP Injection Points

Profhilo is administered using the BAP (Bio Aesthetic Points) technique, which involves five strategic injection points per side of the face. These points were selected for their safety and optimal diffusion capability.

BAP Point Locations:

1. Malar region (mid-cheek)
2. Nasal base
3. Chin
4. Preauricular area
5. Posterior mandible

With only 10 injections per session, Profhilo achieves a uniform and effective spread across the facial tissues.

IBSA recommends two sessions spaced one month apart for optimal results.

Body Applications

Profhilo is not limited to the face. Adapted protocols exist for:

• Neck (Profhilo Neck)
• Décolleté
• Inner arms
• Abdomen
• Knees

These areas, often affected by skin laxity and dehydration, respond particularly well to Profhilo’s dual-action effects.

Clinical Evidence

Several clinical studies support Profhilo’s safety and efficacy:

• Improved skin elasticity (measured with Cutometer)
• Increased dermal density and hydration
• High patient and physician satisfaction rates

A widely cited study published in PubMed (PMID: 31298185) confirmed significant improvements in skin quality after just two sessions of Profhilo treatment.

More evidence: ClinicalTrials.gov

Comparison: Profhilo vs Traditional Hyaluronic Acid Fillers

Profhilo is ideal for patients seeking rejuvenation without added volume, or as a complement to other treatments such as botulinum toxin or fillers.

Indications and Patient Profiles

Profhilo is indicated for:

• Dull, dehydrated, or lax skin
• Mild to moderate skin aging
• Young patients for preventive care
• Patients hesitant about volumizing treatments

Common contraindications include:

• Pregnancy and breastfeeding
• Active skin infections
• Uncontrolled autoimmune diseases

Treatment Protocol and Maintenance

1. Initial phase: 2 sessions spaced 1 month apart
2. Maintenance: 1 session every 6–9 months

Profhilo can be combined with:

• Radiofrequency
• Microneedling
• PRP (Platelet-Rich Plasma)

Patient education is key: Profhilo improves skin quality but does not replace volumizing or structural treatments.

Benefits for Aesthetic Clinics

• Versatile product for face and body
• High demand from patients seeking natural results
• Quick application (approx. 15 minutes)
• Progressive, visible results without downtime
• Easy integration into combination protocols

Frequently Asked Questions (Patients)

Is the treatment painful?
Only 10 injections using a fine needle are required. Discomfort is minimal and short-lived.

When will I see results?
Visible improvements typically appear 10–15 days after the first session and are optimized after the second.

Does Profhilo replace facial fillers?
No. These are complementary treatments. Profhilo enhances skin quality, not volume.

Is it effective for the neck or chest?
Yes. Specific protocols are available for those areas.

Conclusion

Profhilo hyaluronic acid has established itself as a clinically backed, effective, and increasingly popular solution in aesthetic medicine. Its ability to enhance skin quality without volume makes it a must-have tool in modern facial and body rejuvenation protocols.

For clinics prioritizing natural outcomes, scientific backing, and high patient satisfaction, Profhilo is a smart and reliable choice.

References and Resources

1. IBSA Derma – Profhilo
2. PubMed – Clinical Study on Profhilo
3. ClinicalTrials – Profhilo Results