Profhilo represents a paradigm shift in injectable aesthetic treatments. Neither a traditional filler nor a mesotherapy agent, Profhilo is classified as a bioremodeling injectable, and Profhilo hyaluronic acid is designed to improve skin laxity, hydration, and firmness through high-concentration, ultrapure hyaluronic acid (HA). This article explores Profhilo’s mechanism of action, its unique BAP injection protocol, and how it compares to conventional dermal fillers.

1. What is Profhilo and How Does It Work?

Profhilo is an innovative product developed by IBSA Derma. It contains one of the highest concentrations of hyaluronic acid on the market: 64 mg of ultrapure HA in a 2 ml syringe. Unlike traditional fillers, Profhilo is not cross-linked and is free of BDDE (a common cross-linking agent).

The formula uses NAHYCO® hybrid technology, which thermally bonds high- and low-molecular-weight HA chains without chemical additives. The result is a gel with high spreadability and deep tissue integration, ideal for improving overall skin quality without adding volume.

Profhilo does not act as a filler to restore volume but instead improves skin architecture and hydration, making it suitable for subtle yet noticeable rejuvenation.

2. Dual Action: Hydration and Biostimulation

Profhilo offers a dual mechanism:

• Hydration: The high HA content draws water into the dermis, improving skin turgor and elasticity.
• Biostimulation: Profhilo stimulates fibroblasts to produce collagen types I and III, elastin, and endogenous HA, supporting dermal remodeling and tightening.

Clinical studies demonstrate visible improvements in:

• Fine lines and wrinkles
• Skin texture and tone
• Firmness and elasticity

Source: IBSA Clinical Overview

Additionally, Profhilo’s dual-phase release creates both immediate hydration effects and long-term remodeling, distinguishing it from both volumizing fillers and superficial skin boosters.

3. The BAP Technique (Bio Aesthetic Points)

Profhilo is administered through a patented injection protocol known as the BAP technique. BAP stands for “Bio Aesthetic Points” and refers to 5 strategic injection sites on each side of the face.

Why these points?

• Avoid major blood vessels and nerves
• Optimize diffusion across facial areas
• Ensure patient comfort and minimal downtime

These points are located in:

• Zygomatic region
• Nasal base
• Chin
• Preauricular area
• Mandibular angle

This technique allows for full facial coverage with just 10 injection points per session.

Reference: Profhilo BAP Protocol – IBSA Training Manual

The technique can also be adapted to off-label areas, such as the neck and décolleté, using similar spacing principles.

4. Clinical Evidence and Safety

Multiple clinical trials and peer-reviewed studies confirm Profhilo’s efficacy and safety:

• Improved skin firmness and hydration after 2 sessions spaced 4 weeks apart
• High patient satisfaction rates
• Minimal adverse reactions (mostly mild and transient)

Study example: PubMed – Efficacy of Profhilo in Facial Aging

In clinical use, patients often report improved skin luminosity and elasticity within 2 weeks of the first treatment. Dermatologists also highlight the predictability of outcomes, even in patients with thinning or mature skin.

5. Profhilo vs Traditional Dermal Fillers

Profhilo is ideal for patients seeking skin rejuvenation without facial volume enhancement, or as a complement to fillers and neuromodulators.

It also appeals to patients hesitant about traditional injectables, offering a natural alternative with no risk of overcorrection or heavy features.

6. Indications Beyond the Face

In addition to the face, Profhilo is also effective in areas such as:

• Neck
• Décolleté
• Inner arms
• Abdomen
• Knees

These areas benefit from the product’s deep hydration and ability to stimulate collagen and elastin, improving both skin tone and texture.

Product extension: Profhilo Body by IBSA

7. How to Integrate Profhilo into Clinical Practice

Best practices include:

• 2 initial sessions, spaced 4 weeks apart
• Maintenance every 6 months
• Combine with micro-needling, PRP, or peelings for enhanced results

Common clinical protocols:

• Use Profhilo as a pre-treatment before filler application to optimize skin quality
• Combine with energy-based devices (radiofrequency, ultrasound) for synergistic skin tightening
• Offer Profhilo as part of preventative anti-aging plans for patients aged 30+

Patient education is crucial: Emphasize that Profhilo enhances skin quality rather than altering facial structure.

8. Real-World Results and Case Integration

Aesthetic clinics often report that Profhilo boosts overall patient satisfaction, especially when used in:

• Bridal skincare protocols
• Men’s facial rejuvenation
• Post-weight-loss skin laxity

Testimonials from aesthetic doctors frequently highlight:

• “Patients notice visible skin improvement within 10–14 days.”
• “Profhilo is our go-to solution for crepey neck skin and dehydrated cheeks.”

9. Addressing Patient FAQs

Is Profhilo painful?
Most patients report mild discomfort, and the use of a fine needle and minimal injection points makes the procedure well tolerated.

How soon will I see results?
Improvements in texture and hydration are often visible within the first 2 weeks. Full effects peak after the second session.

Can it replace fillers or botulinum toxin?
No. Profhilo is a complementary treatment focused on skin quality, not volume or dynamic wrinkles.

Is it suitable for men?
Yes. Profhilo is often preferred by male patients due to its natural finish and lack of visible augmentation.

11. References

1. IBSA Derma Official Site – Profhilo
2. PubMed – Bioremodeling with Hyaluronic Acid
3. ClinicalTrials.gov – Profhilo Efficacy
4. IBSA Product Brochure – Profhilo Body